bms 202 (Selleck Chemicals)
Structured Review

Bms 202, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 30 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/bms+202/BMS202/pmc12971183-30-0-7
Average 93 stars, based on 30 article reviews
Images
1) Product Images from "Intracellular Localization of PD-L1 in Rab10-positive Open Tubular Endosome System of Cancer Cells"
Article Title: Intracellular Localization of PD-L1 in Rab10-positive Open Tubular Endosome System of Cancer Cells
Journal: Acta Histochemica et Cytochemica
doi: 10.1267/ahc.25-00060
Figure Legend Snippet: Dimerized PD-L1 by BMS-202 treatment was internalized into early endosomes and delivered to lysosomes. HeLaM cells co-expressing GFP-PD-L1 and mCherry-Rab5 or mCherry-Lgp120 were treated with BMS-202. ( A ) GFP-PD-L1, which was localized to the cell surface, Rab10-positive tubules, and Rab10-negative small vesicles in HeLaM cells at 0 min, was internalized into Rab5-positive early endosomes 30 min after BMS-202 treatment. ( B ) After120 min, GFP-PD-L1 accumulated in perinuclear vesicles. Some of these are mCherry-Lgp120-positive lysosomes. Bars = 10 μm.
Techniques Used: Expressing
Figure Legend Snippet: Expression of mCherry-CMTM6 retains PD-L1 on the cell surface and tubules even after BMS-202 treatment. HeLaM cells co-expressing GFP-PD-L1 and mCherry-CMTM6 were treated with BMS-202. In cells overexpressing CMTM6, GFP-PD-L1 was predominantly observed on the membranes of cell surface and Rab10-positive tubules even after BMS-202 treatment. Bars = 10 μm.
Techniques Used: Expressing
Related Articles
Positive Control:Article Title: Rosmarinic acid in combination with ginsenoside Rg1 suppresses colon cancer metastasis via co-inhition of COX-2 and PD1/PD-L1 signaling axis. Article Snippet: Metastasis of colorectal cancer (CRC) is a leading cause of mortality among CRC patients.. Elevated COX-2 and PD-L1 expression in colon cancer tissue has been linked to distant metastasis of tumor cells.. Although COX-2 inhibitors and immune checkpoint inhibitors demonstrate improved anti-tumor efficacy, their toxicity and variable therapeutic effects in individual patients raise concerns. Article Title: Turning a Tumor Microenvironment Pitfall into Opportunity: Discovery of Benzamidoxime as PD-L1 Ligand with pH-Dependent Potency Article Snippet: .. Article Title: Uncovering the colorectal cancer immunotherapeutic potential: Evening primrose (Oenothera biennis) root extract and its active compound oenothein B targeting the PD-1/PD-L1 blockade. Article Snippet: .. The luminescence was analyzed after an additional 2 h. For the positive control, a human PD-1-neutralizing antibody (αPD-1, #71,120, BPS Bioscience), Synthesized:Article Title: Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design Article Snippet: .. Inhibition:Article Title: Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment Article Snippet: .. Cells (0.1×10 6 cells) were tested for PD-1/PD-L1 inhibition by co-incubation of hit compounds, DMSO (background), |