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bms 202  (Selleck Chemicals)


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    Structured Review

    Selleck Chemicals bms 202
    Dimerized PD-L1 <t>by</t> <t>BMS-202</t> treatment was internalized into early endosomes and delivered to lysosomes. HeLaM cells co-expressing GFP-PD-L1 and mCherry-Rab5 or mCherry-Lgp120 were treated with BMS-202. ( A ) GFP-PD-L1, which was localized to the cell surface, Rab10-positive tubules, and Rab10-negative small vesicles in HeLaM cells at 0 min, was internalized into Rab5-positive early endosomes 30 min after BMS-202 treatment. ( B ) After120 min, GFP-PD-L1 accumulated in perinuclear vesicles. Some of these are mCherry-Lgp120-positive lysosomes. Bars = 10 μm.
    Bms 202, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 30 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bms+202/BMS202/pmc12971183-30-0-7
    Average 93 stars, based on 30 article reviews
    bms 202 - by Bioz Stars, 2026-09
    93/100 stars

    Images

    1) Product Images from "Intracellular Localization of PD-L1 in Rab10-positive Open Tubular Endosome System of Cancer Cells"

    Article Title: Intracellular Localization of PD-L1 in Rab10-positive Open Tubular Endosome System of Cancer Cells

    Journal: Acta Histochemica et Cytochemica

    doi: 10.1267/ahc.25-00060

    Dimerized PD-L1 by BMS-202 treatment was internalized into early endosomes and delivered to lysosomes. HeLaM cells co-expressing GFP-PD-L1 and mCherry-Rab5 or mCherry-Lgp120 were treated with BMS-202. ( A ) GFP-PD-L1, which was localized to the cell surface, Rab10-positive tubules, and Rab10-negative small vesicles in HeLaM cells at 0 min, was internalized into Rab5-positive early endosomes 30 min after BMS-202 treatment. ( B ) After120 min, GFP-PD-L1 accumulated in perinuclear vesicles. Some of these are mCherry-Lgp120-positive lysosomes. Bars = 10 μm.
    Figure Legend Snippet: Dimerized PD-L1 by BMS-202 treatment was internalized into early endosomes and delivered to lysosomes. HeLaM cells co-expressing GFP-PD-L1 and mCherry-Rab5 or mCherry-Lgp120 were treated with BMS-202. ( A ) GFP-PD-L1, which was localized to the cell surface, Rab10-positive tubules, and Rab10-negative small vesicles in HeLaM cells at 0 min, was internalized into Rab5-positive early endosomes 30 min after BMS-202 treatment. ( B ) After120 min, GFP-PD-L1 accumulated in perinuclear vesicles. Some of these are mCherry-Lgp120-positive lysosomes. Bars = 10 μm.

    Techniques Used: Expressing

    Expression of mCherry-CMTM6 retains PD-L1 on the cell surface and tubules even after BMS-202 treatment. HeLaM cells co-expressing GFP-PD-L1 and mCherry-CMTM6 were treated with BMS-202. In cells overexpressing CMTM6, GFP-PD-L1 was predominantly observed on the membranes of cell surface and Rab10-positive tubules even after BMS-202 treatment. Bars = 10 μm.
    Figure Legend Snippet: Expression of mCherry-CMTM6 retains PD-L1 on the cell surface and tubules even after BMS-202 treatment. HeLaM cells co-expressing GFP-PD-L1 and mCherry-CMTM6 were treated with BMS-202. In cells overexpressing CMTM6, GFP-PD-L1 was predominantly observed on the membranes of cell surface and Rab10-positive tubules even after BMS-202 treatment. Bars = 10 μm.

    Techniques Used: Expressing

    Related Articles

    Positive Control:

    Article Title: Rosmarinic acid in combination with ginsenoside Rg1 suppresses colon cancer metastasis via co-inhition of COX-2 and PD1/PD-L1 signaling axis.
    Article Snippet: Metastasis of colorectal cancer (CRC) is a leading cause of mortality among CRC patients.. Elevated COX-2 and PD-L1 expression in colon cancer tissue has been linked to distant metastasis of tumor cells.. Although COX-2 inhibitors and immune checkpoint inhibitors demonstrate improved anti-tumor efficacy, their toxicity and variable therapeutic effects in individual patients raise concerns.

    Article Title: Turning a Tumor Microenvironment Pitfall into Opportunity: Discovery of Benzamidoxime as PD-L1 Ligand with pH-Dependent Potency
    Article Snippet: .. BMS-202 ( 5 ) was purchased from Selleckchem (Selleckchem, Houston, DX, USA) and used as positive control. ..

    Article Title: Uncovering the colorectal cancer immunotherapeutic potential: Evening primrose (Oenothera biennis) root extract and its active compound oenothein B targeting the PD-1/PD-L1 blockade.
    Article Snippet: .. The luminescence was analyzed after an additional 2 h. For the positive control, a human PD-1-neutralizing antibody (αPD-1, #71,120, BPS Bioscience), Bristol–Myers Squibb (BMS)− 202 (BMS-202, S7912, Selleck Chemicals LLC, Houston, Texas, USA), or a human PD-L1-neutralizing antibody (αPD-L1, #71,213, BPS Bioscience) was employed. .. Cell viability was assessed using Dojindo Cell Counting Kit-8 (Rockville, MD, USA).

    Synthesized:

    Article Title: Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design
    Article Snippet: .. BMS-202 and P18 were purchased as pure substances from Selleck Chemicals LCC and InvivoChem LLC, respectively, while RS39 was synthesized according to our previously published procedure . ..

    Inhibition:

    Article Title: Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment
    Article Snippet: .. Cells (0.1×10 6 cells) were tested for PD-1/PD-L1 inhibition by co-incubation of hit compounds, DMSO (background), BMS-202 (Selleckchem) and anti-human PD-L1 (Bio X Cell, Clone 29E.2A3) (positive controls) for 72 hours in 2 mL DMEM media. ..



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    Selleck Chemicals bms 202
    Dimerized PD-L1 <t>by</t> <t>BMS-202</t> treatment was internalized into early endosomes and delivered to lysosomes. HeLaM cells co-expressing GFP-PD-L1 and mCherry-Rab5 or mCherry-Lgp120 were treated with BMS-202. ( A ) GFP-PD-L1, which was localized to the cell surface, Rab10-positive tubules, and Rab10-negative small vesicles in HeLaM cells at 0 min, was internalized into Rab5-positive early endosomes 30 min after BMS-202 treatment. ( B ) After120 min, GFP-PD-L1 accumulated in perinuclear vesicles. Some of these are mCherry-Lgp120-positive lysosomes. Bars = 10 μm.
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    https://www.bioz.com/product/bms+202/BMS202/pmc12971183-30-0-7
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    Image Search Results


    Dimerized PD-L1 by BMS-202 treatment was internalized into early endosomes and delivered to lysosomes. HeLaM cells co-expressing GFP-PD-L1 and mCherry-Rab5 or mCherry-Lgp120 were treated with BMS-202. ( A ) GFP-PD-L1, which was localized to the cell surface, Rab10-positive tubules, and Rab10-negative small vesicles in HeLaM cells at 0 min, was internalized into Rab5-positive early endosomes 30 min after BMS-202 treatment. ( B ) After120 min, GFP-PD-L1 accumulated in perinuclear vesicles. Some of these are mCherry-Lgp120-positive lysosomes. Bars = 10 μm.

    Journal: Acta Histochemica et Cytochemica

    Article Title: Intracellular Localization of PD-L1 in Rab10-positive Open Tubular Endosome System of Cancer Cells

    doi: 10.1267/ahc.25-00060

    Figure Lengend Snippet: Dimerized PD-L1 by BMS-202 treatment was internalized into early endosomes and delivered to lysosomes. HeLaM cells co-expressing GFP-PD-L1 and mCherry-Rab5 or mCherry-Lgp120 were treated with BMS-202. ( A ) GFP-PD-L1, which was localized to the cell surface, Rab10-positive tubules, and Rab10-negative small vesicles in HeLaM cells at 0 min, was internalized into Rab5-positive early endosomes 30 min after BMS-202 treatment. ( B ) After120 min, GFP-PD-L1 accumulated in perinuclear vesicles. Some of these are mCherry-Lgp120-positive lysosomes. Bars = 10 μm.

    Article Snippet: BMS-202 (PD-1/PD-L1 inhibitor 2) was purchased from Selleck Biotech (Yokohama, Japan).

    Techniques: Expressing

    Expression of mCherry-CMTM6 retains PD-L1 on the cell surface and tubules even after BMS-202 treatment. HeLaM cells co-expressing GFP-PD-L1 and mCherry-CMTM6 were treated with BMS-202. In cells overexpressing CMTM6, GFP-PD-L1 was predominantly observed on the membranes of cell surface and Rab10-positive tubules even after BMS-202 treatment. Bars = 10 μm.

    Journal: Acta Histochemica et Cytochemica

    Article Title: Intracellular Localization of PD-L1 in Rab10-positive Open Tubular Endosome System of Cancer Cells

    doi: 10.1267/ahc.25-00060

    Figure Lengend Snippet: Expression of mCherry-CMTM6 retains PD-L1 on the cell surface and tubules even after BMS-202 treatment. HeLaM cells co-expressing GFP-PD-L1 and mCherry-CMTM6 were treated with BMS-202. In cells overexpressing CMTM6, GFP-PD-L1 was predominantly observed on the membranes of cell surface and Rab10-positive tubules even after BMS-202 treatment. Bars = 10 μm.

    Article Snippet: BMS-202 (PD-1/PD-L1 inhibitor 2) was purchased from Selleck Biotech (Yokohama, Japan).

    Techniques: Expressing